10/20/2023 0 Comments Antiyoy skinsFurthermore, anthocyanins are natural-occurring plant pigments which are included in this class. The most common polyphenols in plants that have proved potential health benefits are the well-known class of flavonoids. They are able to protect the human organism from free-radical-induced damage to DNA and defend against the harmful UV radiation or pathogen aggressiveness. Dietary polyphenols have gained the attention of researchers worldwide owing to their antioxidant potential. However, the nature and the underlying mechanisms of the most protective effects of polyphenols are still under investigation. ![]() They may protect against an array of chronic diseases or even various cancers, as exhibited in some pre-clinical, clinical, and epidemiologic studies. There are over 15,000 polyphenols identified in nature, widely distributed not only among fruits and vegetables but also in different types of grains, oils, alcoholic and non-alcoholic beverages. ![]() The most abundant compounds with antioxidant potential in the human daily diet are represented by polyphenols. Recent studies involving anthocyanin-based extracts carried out in vitro and in vivo, along with the epidemiological studies, have granted these pigments potential anticarcinogenic properties. Currently, the potential health benefits of these extraordinary molecules are strongly related to their potent antioxidant activity. The worldwide interest of the research community in respect to biochemical and biological aspects of anthocyanins has considerably increased not only due to their wide therapeutic potential but also due to their anticarcinogenic effects. Incontrovertible evidence of various health benefits arising from incorporating anthocyanins in our diet was presented by many researchers. Phytochemicals are secondary plant metabolites, known to stimulate plant reproduction as well to protect against pathogens and phytochemistry, including a systematic study of phytochemicals which has been of significant interest to researchers in the last decades. Following a diet that consists of fruits and vegetables has been associated with a lower frequency of diagnosed patients suffering from several pathologies such as obesity, cardiovascular and neurological diseases, diabetes, Alzheimer’s disease, and finally, yet importantly, cancer, due to their high content in phytochemicals, such as polyphenols. Accordingly, numerous studies based on the hypothesis of the therapeutic potential of fruits and vegetables, as well as several medicinal plants, have been conducted. ![]() Today, it is a generally accepted concept that including fruits and vegetables in our daily diet is beneficial for the prevention of a vast array of human diseases. Additionally, the importance of anthocyanins in topical applications such as their use in cosmetics is also given. We also briefly summarized the anthocyanin chemistry, their rich dietary sources in flowers, fruits, and vegetables, as well as their associated potential health benefits. Accordingly, this work primarily aims to emphasize the most recent improvements on the anticarcinogenic effects of anthocyanins from different plant sources, with an in-depth emphasis on melanoma skin cancer. Plants, in general, have been used in disease treatment for a long time, and medicinal plants are commonly a part of anticancer drugs on the market. Malignant melanoma is considered a highly destructive type of skin cancer due to its particular capacity to grow and spread faster than any other type of cancers. In fact, the incidence of melanoma skin cancer, the type with high mortality, has increased exponentially over the last 30 years, causing the majority of skin cancer deaths. Nevertheless, the metastatic form has a short prognosis. If diagnosed at the early stages, the survival rate of skin cancer is quite high. However, there is no targeted review available regarding the anticarcinogenic effects of dietary anthocyanins on skin cancers. ![]() Until today, numerous studies evaluated the topic of anthocyanins and various types of cancer, regarding the anthocyanins’ preventative and inhibitory effects, underlying molecular mechanisms, and such.
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